Pyridine, 4-isocyanato-
4-Isocyanatopyridine
CAS: 70067-45-7
Molecular Formula: C6H4N2O
Pyridine, 4-isocyanato- - Names and Identifiers
| Name | 4-Isocyanatopyridine |
| Synonyms | 4-Pyridyl isocyanate 4-Isocyanatopyridine 4-isocyanate pyridine Pyridin-4-yl isocyanate Pyridine, 4-isocyanato- |
| CAS | 70067-45-7 |
Pyridine, 4-isocyanato- - Physico-chemical Properties
| Molecular Formula | C6H4N2O |
| Molar Mass | 120.11 |
| Density | 1.12±0.1 g/cm3(Predicted) |
| Melting Point | 160-161 °C |
| Boling Point | 181.9±13.0 °C(Predicted) |
| pKa | 4.83±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Toxic, Lachrymator, Refrigerate |
| MDL | MFCD08436476 |
Pyridine, 4-isocyanato- - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R22 - Harmful if swallowed R23 - Toxic by inhalation R36 - Irritating to the eyes R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
Pyridine, 4-isocyanato- - Introduction
4-Isocyanatopyridine is an organic compound with the chemical formula C6H4N2O. The following is an introduction to the properties, uses, preparation methods and safety information of 4-isonitrilopyridine:
Nature:
-Appearance: 4-Isonitrilopyridine is a colorless to pale yellow crystal or solid.
-Solubility: It is soluble in alcohols, ethers and chlorinated hydrocarbons and other organic solvents, slightly soluble in water.
-Melting point: The melting point of 4-isonitrilopyridine is 82-85°C.
-use: 4-isonitrile pyridine is an important organic synthesis intermediates, widely used in medicine, pesticides and dyes and other fields. It can be used in the synthesis of pyridine derivatives, such as a variety of environmentally friendly sulfur leaf sulfonamide antibiotics.
Preparation Method:
-4-Isonitrilopyridine can be prepared by reacting 2-aminopyridine with cyanogen chloride. First, 2-aminopyridine is reacted with thionyl chloride under alkaline conditions to obtain 2-pyridinethiol, then chlorosulfonated to obtain chlorosulfonyl compounds, and finally reacted with sodium cyanide to form 4-isonitrilopyridine.
-Another preparation method is to react pyridine-4-carboxylic acid with a nitrilizing agent (such as sodium cyanide) to produce 4-isonitrilopyridine.
Safety Information:
-4-Isonitrilopyridine is a flammable substance and should be kept away from fire and high temperature areas.
-Wear appropriate protective equipment such as gloves, safety glasses and protective face masks during handling and use.
-Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with plenty of water. If you feel unwell, you should seek medical attention in time.
-Pay attention to storage conditions, store 4-isonitrilopyridine in a cool, dry, well-ventilated place, and avoid contact with oxidants, acids and alkalis.
Nature:
-Appearance: 4-Isonitrilopyridine is a colorless to pale yellow crystal or solid.
-Solubility: It is soluble in alcohols, ethers and chlorinated hydrocarbons and other organic solvents, slightly soluble in water.
-Melting point: The melting point of 4-isonitrilopyridine is 82-85°C.
-use: 4-isonitrile pyridine is an important organic synthesis intermediates, widely used in medicine, pesticides and dyes and other fields. It can be used in the synthesis of pyridine derivatives, such as a variety of environmentally friendly sulfur leaf sulfonamide antibiotics.
Preparation Method:
-4-Isonitrilopyridine can be prepared by reacting 2-aminopyridine with cyanogen chloride. First, 2-aminopyridine is reacted with thionyl chloride under alkaline conditions to obtain 2-pyridinethiol, then chlorosulfonated to obtain chlorosulfonyl compounds, and finally reacted with sodium cyanide to form 4-isonitrilopyridine.
-Another preparation method is to react pyridine-4-carboxylic acid with a nitrilizing agent (such as sodium cyanide) to produce 4-isonitrilopyridine.
Safety Information:
-4-Isonitrilopyridine is a flammable substance and should be kept away from fire and high temperature areas.
-Wear appropriate protective equipment such as gloves, safety glasses and protective face masks during handling and use.
-Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with plenty of water. If you feel unwell, you should seek medical attention in time.
-Pay attention to storage conditions, store 4-isonitrilopyridine in a cool, dry, well-ventilated place, and avoid contact with oxidants, acids and alkalis.
Last Update：2024-04-09 21:01:54
